If you want to be a part of the history and culture that is Rome, staying in a Rome Hotel where you can walk out the door and into the essence of the city is recommended. Of course, hotels in Rome are more expensive the closer you are to all of the major attractions, but well worth the extra costs involved.
Look at a map of Rome before reserving your hotel in Rome. The area east of the Tiber River and west of Station Termini is prime Rome hotels area, and you will be close to everything.
If you’re looking for a really lively area to stay, you’ll want to check out the area between Piazza Navona and Piazza Barberini. There are some expensive rooms in this area, but there are also many more cheap hotels in Rome here in the form of small family-run independent hotels. These hotels are often more unique and authentic in flavor than the larger chains as well.